The Painkiller Medicines are made available by us that are powerful drugs that interfere with the nervous systems transmission of the nerve signals we perceive as pain. Most painkillers also stimulate portions of the brain associated with pleasure. Thus, in addition to blocking pain, they produce a high. Tapentadol 100 mg is used to treat moderate to severe pain. It can treat all types of body pain. It is used by people who are expected to need medication to relieve pain around-the-clock. The Painkiller Medicines are very useful.